Prosci/BID重组蛋白/91-089/0.05毫克
商品编号：
91-089
品牌：
prosci-inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | E.coli |
| SEQUENCE: | Met1-Asp195 |
| FUSIONTAG: | TagFree |
| TESTEDAPPLICATIONS: | |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
| PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 21.99kD |
| PHYSICALSTATE: | Liquid |
| BUFFER: | Suppliedasa0.2umfilteredsolutionof20mMPB,100mMKCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
| STORAGECONDITIONS: | Storeat-20˚C,stablefor6monthsafterreceipt. Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | BH3-InteractingDomainDeathAgoNIST,p22BID,BID |
|---|---|
| ACCESSIONNO.: | P55957 |
Background
| BH3-InteractingDomainDeathAgonist(BID)isamemberoftheBcl-2proteinfamilywhichregulatesoutermitochondrialmembranepermeABIlity.BIDisapro-apoptoticmemberthatcausescytochromectobereleasedfromthemitochondriaintermembranespaceintothecytosol.InteractionofBidwithBakcausesalteredmitochondrialmembranepermeability.BIDcontainsonlytheBH3domain,whichisrequiredforitsinteractionwiththeBcl-2familyproteinsandforitspro-deathactivity.BIDissusceptIBLetoproteolyticcleavagebycaspases,calpains,GranzymeBandcathepsins.Itisanintegratingkeyregulatoroftheintrinsicdeathpathwaythatamplifiescaspase-dependentandcaspase-independentexecutionofneuronalapoptosis.ThereforepharmacologicalinhibitionofBIDprovidesapromisingtherapeuticstrategyinneurologicaldiseaseswhereprogrammedcelldeathisprominent,andalsoofferanewstrategyforthetreatmentofacuterenalfailureassociatedwithischemia-reperfusion.BIDreceivesdirectinputsfromakeyregulatorofthecellcyclearrest/DNArepairmachinery(ATM),andthereforeisanexcellentcandidatetocoordinategenotoxicstressresponsesandapoptoticcelldeath.BIDisanovelpro-apoptosisBcl-2familyproteinthatisactivatedbycaspase8inresponsetoFas/TNF-R1deathreceptorsignals.DeletionofBIDinhibitscarcinogenesisintheliver,althoughthisgeneticalterationpromotestumOrigenesisinthemyeloidcells.ThisislikelyrelatedtothefunctionofBIDtopromotecellcycleprogressionintoSphase.BIDcouldbealsoinvolvedinthemaintenanceofgenomicstabilitybyengagingatmitosischeckpoint. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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