Prosci/ACK1 Antibody/63-156/400 ul
商品编号：
63-156
品牌：
prosci-inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Bovine |
| TESTED APPLICATIONS: | WB |
| APPLICATIONS: | For WB starting dilution is: 1:1000 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| PREDICTED MOLECULAR WEIGHT: | 115 kDa |
| IMMUNOGEN: | This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-411 amino acids from the Central region of human ACK1. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | 2 mg/ml |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1 |
|---|---|
| ACCESSION NO.: | Q07912 |
| PROTEIN GI NO.: | 229462980 |
| OFFICIAL SYMBOL: | TNK2 |
| GENE ID: | 10188 |
Background
| BACKGROUND: | ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. |
|---|---|
| REFERENCES: | 1) Yokoyama, N., et al., J. Biol. Chem. 278(48):47713-47723 (2003). | 2) Manser, E., et al., Nature 363(6427):364-367 (1993). |
品牌介绍
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