Prosci/腺泡抗体/2217/0.1mg
商品编号：
2217
品牌：
prosci-inc
市场价：
¥6500.00
美元价：
3900.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Mouse: (100%) |
| TESTED APPLICATIONS: | ELISA, ICC, IF, WB |
| APPLICATIONS: | Acinus antibody antibody can be used for detection of Acinus by Western blot at 0.5 μg/mL. An approximate 220 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 0.5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| POSITIVE CONTROL: | 1) Cat. No. 1204 - K562 Cell Lysate |
| 2) Cat. No. 17-004 - K-562 Cell Slide | |
| PREDICTED MOLECULAR WEIGHT: | 220 kDa |
| IMMUNOGEN: | Acinus antibody was raised against a peptide corresponding to amino acids near the carbosy terminus of human AcinusL, which are identical to those of mouse Acinus. The immunogen is located within the last 50 amino acids of Acinus. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | Acinus Antibody is affinity chromatography purified via peptide column. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Acinus Antibody is supplied in PBS containing 0.02% sodium azide. |
| STORAGE CONDITIONS: | Acinus antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | Acinus Antibody: ACN, ACINUS, fSAP152, KIAA0670, Apoptotic chromatin condensation inducer in the nucleus, Acinus |
|---|---|
| ACCESSION NO.: | AAD56724 |
| PROTEIN GI NO.: | 5931959 |
| OFFICIAL SYMBOL: | ACIN1 |
| GENE ID: | 22985 |
Background
| BACKGROUND: | Acinus Antibody: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'. |
|---|---|
| REFERENCES: | 1) Zamzami N, Kroemer G. Condensed matter in cell death. Nature 1999 ;401:127-8. | 2) Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 1999 401:168-73. |
品牌介绍
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