Prosci/Acinus Antibody/2215/0.02 mg
商品编号：
2215
品牌：
prosci-inc
市场价：
¥1580.00
美元价：
948.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predictedspeciesreactivitybasedonimmunogensequence:Mouse:(100%) |
| TESTEDAPPLICATIONS: | ELISA,ICC,IF,WB |
| APPLICATIONS: | AcinusantibodycanbeusedfordetectionofAcinusbyWesternblotat1μg/mL.Anapproximate220kDabandcanbedetected.Antibodycanalsobeusedforimmunocytochemistrystartingat10μg/mL.Forimmunofluorescencestartat10μg/mL. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1204-K562CellLysate |
| 2)Cat.No.17-004-K-562CellSlide | |
| 3)Cat.No.17-001-HeLaCellSlide | |
| PREDICTEDMOLECULARWEIGHT: | 220kDa |
| IMMUNOGEN: | AcinusantibodywasraisedagainstapeptidecorrespondingtoaminoacidsneartheC-terminusofthecleavedactivepeptidep17,whichareidenticaltothoseofmouseAcinus. Theimmunogenislocatedwithinaminoacids1050-1100ofAcinus. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | AcinusAntibodyisaffinitychromatographypurifiedviapeptidecolumn. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | AcinusAntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| STORAGECONDITIONS: | Acinusantibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | AcinusAntibody:ACN,ACINUS,fSAP152,KIAA0670,Apoptoticchromatincondensationinducerinthenucleus,Acinus |
|---|---|
| ACCESSIONNO.: | AAD56724 |
| PROTEINGINO.: | 5931959 |
| OFFICIALSYMBOL: | ACIN1 |
| GENEID: | 22985 |
Background
| BACKGROUND: | AcinusAntibody:Chromatincondensationandnuclearfragmentation(CCNF)isthehallmarkofapoptosis.CCNFistriggeredbytheactivationofmembersofcaspasefamily,caspaseactivatedDNase(CAD/DFF40),andseveralnovelproteinsincludingAIFandCIDE.AnewinducerofchromatincondensationwasrecentlyidentifiedanddesignatedAcinus(forapoptoticchromatincondensationinducerinthenucleus).Acinusiscleavedbycaspase-3andanadditionalunknownproteasegeneratingasmallactivepeptidep17,whichcauseschromatincondensationinvitrowhenitisaddedtopurifiednuclei.Acinusalsoinducesapoptoticchromatincondensationincells.Acinusisubiquitouslyexpressed.ThreedifferentsplicedformsofAcinushavebeenidentifiedinhumanandmouseanddesignatedAcinusL,AcinusSandAcinusS". |
|---|---|
| REFERENCES: | 1)ZamzamiN,KroemerG.Condensedmatterincelldeath.Nature1999;401:127-8. | 2)SaharaS,AotoM,EguchiY,ImamotoN,YonedaY,TsujimotoY.Acinusisacaspase-3-activatedproteinrequiredforapoptoticchromatincondensation.Nature1999401:168-73. |
品牌介绍
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