Prosci/BAFF重组蛋白（FITC）/96-814/25μg
商品编号：
96-814
品牌：
prosci-inc
市场价：
¥8500.00
美元价：
5100.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Ala134-Leu285 |
| FUSIONTAG: | FcTag |
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedHumanBCMA,FcTagat10ug/mL(100uL/well)canbindFITC-LabeledHumanBAFF,FcTagwithalinearrangeof0.31-1.25ug/mL(QCtested). |
Properties
| PURITY: | >95%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 44.5kDa |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | PBS,pH7.4 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles.Avoidexposuretolight. |
AdditionalInfo
| ALTERNATENAMES: | TNFSF13B,BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,ZTNF4 |
|---|---|
| ACCESSIONNO.: | AAH20674.1 |
Background
| B-cellactivatingfactor(BAFF)isalsoknownastumornecrosisfactorligandsuperfamilymember13B,TNFSF13B,BAFF,BLymphocyteStimulator(BLyS),clusterofdifferentiation257(CD257),DTL,TNF-andAPOL-relatedleukocyteexpressedligand(TALL-1),THANK,TNFSF20,ZTNF4,andisacytokinethatbelongstothetumornecrosisfactor(TNF)ligandfamily.ThiscytokineisaligandforreceptorsTNFRSF13B/TACI,TNFRSF17/BCMA,andTNFRSF13C/BAFFR.ThiscytokineisexpressedinBcelllineagecells,andactsasapotentBcellactivator.IthasbeenalsoshowntoplayanimportantroleintheproliferationanddifferentiationofBcells.Itisexpressedastransmembraneproteinonvariouscelltypesincludingmonocytes,dendriticcellsandbonemarrowstromalcells.BAFFisthenaturalligandofthreeunusualtumornecrosisfactorreceptorsnamedBAFF-R,TACI,andBCMA,allofwhichhavedifferingbindingaffinitiesforit.ThesereceptorsareexpressedmainlyonmatureBlymphocytes(TACIisalsofoundonasubsetofT-cellsandBCMAonplasmacells).TACIbindsworstsinceitsaffinityishigherforaproteinsimilartoBAFF,calledaproliferation-inducingligand(APRIL).BCMAdisplaysanintermediatebindingphenotypeandwillworkwitheitherBAFForAPRILtovaryingdegrees.SignalingthroughBAFF-RandBCMAstimulatesBlymphocytestoundergoproliferationandtocounterapoptosis.Alltheseligandsactasheterotrimers(i.e.threeofthesamemolecule)interactingwithheterotrimericreceptors,althoughBAFFhasbeenknowntobeactiveaseitherahetero-orhomotrimer.BAFFactsasapotentBcellactivatorandhasbeenshowntoplayanimportantroleintheproliferationanddifferentiationofBcells. |
品牌介绍
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