Prosci/BAFF Recombinant Protein/96-055/0.1 mg
商品编号：
96-055
品牌：
prosci-inc
市场价：
¥10000.00
美元价：
6000.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Ala134-Leu285 |
| FUSIONTAG: | N-FcTag |
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforWB.Forresearchuseonly. |
Properties
| PURITY: | >96%asdeterminedbySDS-PAGE. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 44.5kDa |
| PHYSICALSTATE: | Lyopholized |
| BUFFER: | 50mMtris,100mMglycine,pH7.5 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | TNFSF13B,BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,ZTNF4 |
|---|---|
| ACCESSIONNO.: | AAH20674.1 |
Background
| B-cellactivatingfactor(BAFF)isalsoknownastumornecrosisfactorligandsuperfamilymember13B,TNFSF13B,BAFF,BLymphocyteStimulator(BLyS),clusterofdifferentiation257(CD257),DTL,TNF-andAPOL-relatedleukocyteexpressedligand(TALL-1),THANK,TNFSF20,ZTNF4,andisacytokinethatbelongstothetumornecrosisfactor(TNF)ligandfamily.ThiscytokineisaligandforreceptorsTNFRSF13B/TACI,TNFRSF17/BCMA,andTNFRSF13C/BAFFR.ThiscytokineisexpressedinBcelllineagecells,andactsasapotentBcellactivator.IthasbeenalsoshowntoplayanimportantroleintheproliferationanddifferentiationofBcells.Itisexpressedastransmembraneproteinonvariouscelltypesincludingmonocytes,dendriticcellsandbonemarrowstromalcells.BAFFisthenaturalligandofthreeunusualtumornecrosisfactorreceptorsnamedBAFF-R,TACI,andBCMA,allofwhichhavedifferingbindingaffinitiesforit.ThesereceptorsareexpressedmainlyonmatureBlymphocytes(TACIisalsofoundonasubsetofT-cellsandBCMAonplasmacells).TACIbindsworstsinceitsaffinityishigherforaproteinsimilartoBAFF,calledaproliferation-inducingligand(APRIL).BCMAdisplaysanintermediatebindingphenotypeandwillworkwitheitherBAFForAPRILtovaryingdegrees.SignalingthroughBAFF-RandBCMAstimulatesBlymphocytestoundergoproliferationandtocounterapoptosis.Alltheseligandsactasheterotrimers(i.e.threeofthesamemolecule)interactingwithheterotrimericreceptors,althoughBAFFhasbeenknowntobeactiveaseitherahetero-orhomotrimer.BAFFactsasapotentBcellactivatorandhasbeenshowntoplayanimportantroleintheproliferationanddifferentiationofBcells. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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