Prosci/BACE1重组蛋白/96-052/0.2 mg
商品编号：
96-052
品牌：
prosci-inc
市场价：
¥7000.00
美元价：
4200.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Thr22-Thr457 |
| FUSIONTAG: | N-FcTag |
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforWB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | Measuredbyitsabilitytocleaveafluorogenicpeptidesubstrate,Mca-SEVNLDAEFRK(Dpn)RR-NH2.Thespecificactivityis>1.5pmoles/min/μg. |
Properties
| PURITY: | >85%asdeterminedbySDS-PAGE. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 75kDa |
| PHYSICALSTATE: | Lyopholized |
| BUFFER: | 50mMtris,100mMglycine,pH7.5 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | BACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin-2 |
|---|---|
| ACCESSIONNO.: | NP_036236.1 |
Background
| Beta-secretase1(BACE1)isalsoknownasbeta-siteAPPcleavingenzyme1(beta-siteamyloidprecursorproteincleavingenzyme1),memapsin-2(membrane-associatedasparticprotease2),andaspartylprotease2(ASP2),β-Secretase,andisamemberofthepeptidaseA1proteinfamily,BACE1isatypeI integralmembraneglycoproteinandasparticproteasethatisfoundmainlyintheGolgi.BACE1isanaspartic-acidproteaseimportantinthepathogenesisofAlzheimer"sdisease,andintheformationofmyelinsheathsinperipheralnervecells.Thetransmembraneproteincontainstwoactivesiteaspartateresiduesinitsextracellularproteindomainandmayfunctionasadimer.ThisproteaseisresponsIBLefortheproteolyticprocessingoftheamyloidprecursorprotein(APP).Generationofthe40or42aminoacid-longamyloid-βpeptidesthataggregateinthebrainofAlzheimer"spatientsrequirestwosequentialcleavagesoftheAPP.ExtracellularcleavageofAPPbyBACEcreatesasolubleextracellularfragmentandacellmembrane-boundfragmentreferredtoasC99.TheelevationofBACE1levelscanbeinducedbyamyloidplaquessurroundingneuronsatearlystagesofpathologybeforeneurondeathoccurs,andmaydriveapositive-feedbackloopinAD. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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