Prosci/B7-2重组蛋白/96-971/100微克
商品编号：
96-971
品牌：
prosci-inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Mouse |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Val24-Glu245 |
| FUSIONTAG: | HisTag |
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedMouseB7-2,HisTagat2ug/mL(100uL/well)canbindRatCTLA-4,FcTagwithalinearrangeof0.2-6ng/mL(QCtested). |
Properties
| PURITY: | >95%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 27.1kDa |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | PBS,pH7.4 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | CD86,B7-2,B70,CD28LG2,LAB72,MGC34413 |
|---|---|
| ACCESSIONNO.: | NP_062261.3 |
Background
| ClusterofDifferentiation86(CD86)isalsoknownasB-lymphocyteactivationantigenB7-2,isatypeImembraneproteinthatisamemberoftheimmunoglobulinsuperfamily,andisconstitutivelyexpressedoninterdigitatingdendriticcells,Langerhanscells,peripheralblooddendriticcells,memoryBcells,andgerminalcenterBcells.Additionally,B72isexpressedatlowlevelsonmonocytesandcanbeupregulatedthroughinterferonγ.CD86istheligandfortwodifferentproteinsontheTcellsurface:CD28(forautoregulationandintercellularassociation)andCTLA-4(forattenuationofregulationandcellulardisassociation).CD86worksintandemwithCD80toprimeTcells.RecentstudyhasrevealedthatB7-2promotesthegenerationofamatureAPCrepertoireandpromotesAPCfunctionandsurvival.FurThermore,theB7proteinsarealsoinvolvedininnateimmuneresponsesbyactivatingNF-kappaB-signalingpathwayinmacrophages.CD86thusisregardedasapromisingcandidateforimmunetherapy.CD86+macrophagesinHodgkinlymphomapatientsareanindependentMarkerforpotentialnonresponsetofirstline-therapy. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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