Prosci/B7-1重组蛋白/96-969/100μg
商品编号：
96-969
品牌：
prosci-inc
市场价：
¥7000.00
美元价：
4200.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Mouse |
|---|---|
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Val 38 - Lys 245 |
| FUSION TAG: | His Tag |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | This recombinant protein can be used for E, WB. For research use only. |
| BIOLOGICAL ACTIVITY: | Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-1, His Tag at 2 ug/mL (100 uL/well) can bind Mouse CTLA-4, Fc Tag with a linear range of 0.12-0.5 ng/mL (QC tested). |
Properties
| PURITY: | >95% as determined by SDS-PAGE. Endotoxin level is less than 1.0 EU per ug by the LAL method. |
|---|---|
| PREDICTED MOLECULAR WEIGHT: | 25.6 kDa |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | PBS, pH7.4 |
| STORAGE CONDITIONS: | Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles. |
Additional Info
| ALTERNATE NAMES: | CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7 |
|---|---|
| ACCESSION NO.: | Q00609-1 |
Background
| B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-kappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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