Prosci/B细胞连接蛋白重组蛋白/91-991/0.05mg
商品编号：
91-991
品牌：
prosci-inc
市场价：
¥10500.00
美元价：
6300.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCE SPECIES: | E. coli |
| SEQUENCE: | Met1-Ser456 |
| FUSION TAG: | C-6 His tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant protein can be used for biological assays. For research use only. |
Properties
| PURITY: | Greater than 95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. |
|---|---|
| PREDICTED MOLECULAR WEIGHT: | 51.5 kD |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. |
| STORAGE CONDITIONS: | Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months. |
Additional Info
| ALTERNATE NAMES: | B-Cell Linker Protein, B-Cell Adapter Containing a SH2 Domain Protein, B-Cell Adapter Containing a Src Homology 2 Domain Protein, Cytoplasmic Adapter Protein, Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa, SLP-65, BLNK, BASH, SLP65 |
|---|---|
| ACCESSION NO.: | Q8WV28 |
| PROTEIN GI NO.: | 530384505 |
Background
| B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
联络我们
