Prosci/ACACA抗体/58-978/400微升
商品编号：
58-978
品牌：
prosci-inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Bovine |
| TESTED APPLICATIONS: | WB |
| APPLICATIONS: | For WB starting dilution is: 1:1000 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| PREDICTED MOLECULAR WEIGHT: | 266 kDa |
| IMMUNOGEN: | This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | This antibody is purified through a protein A column, followed by peptide affinity purification. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | 0.5 mg/ml |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA |
|---|---|
| ACCESSION NO.: | Q13085 |
| PROTEIN GI NO.: | 118601083 |
| OFFICIAL SYMBOL: | ACACA |
| GENE ID: | 31 |
Background
| BACKGROUND: | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. |
|---|---|
| REFERENCES: | 1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) | 2) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) | 3) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : | 4) Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010) |
品牌介绍
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