
Prosci/ABL1抗体/63-153/400微升
商品编号:
63-153
品牌:
prosci-inc
市场价:
¥7500.00
美元价:
4500.00
产品分类:
重组抗体
公司分类:
Recombinant_antibodies
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Specifications
SPECIES REACTIVITY: | Human |
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HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Mouse |
TESTED APPLICATIONS: | WB |
APPLICATIONS: | For WB starting dilution is: 1:1000 |
USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
PREDICTED MOLECULAR WEIGHT: | 123 kDa |
IMMUNOGEN: | This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1. |
HOST SPECIES: | Rabbit |
Properties
PURIFICATION: | This antibody is purified through a protein A column, followed by peptide affinity purification. |
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PHYSICAL STATE: | Liquid |
BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
CONCENTRATION: | 0.28 mg/ml |
STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
CLONALITY: | Polyclonal |
ISOTYPE: | Rabbit IgG |
CONJUGATE: | Unconjugated |
Additional Info
ALTERNATE NAMES: | Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7 |
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ACCESSION NO.: | P00519 |
PROTEIN GI NO.: | 85681908 |
OFFICIAL SYMBOL: | ABL1 |
GENE ID: | 25 |
Background
BACKGROUND: | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
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REFERENCES: | 1) Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14053-14058 (2002). | 2) Pisabarro, M.T., et al., J. Mol. Biol. 281(3):513-521 (1998). | 3) Nam, H.J., et al., Structure 4(9):1105-1114 (1996). | 4) Chissoe, S.L., et al., Genomics 27(1):67-82 (1995). |
品牌介绍
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