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Prosci/ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody/79-245/0.1 mg
Prosci/ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody/79-245/0.1 mg
商品编号：
79-245
品牌：
prosci-inc
市场价：
¥6300.00
美元价：
3780.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human, Mouse |
|---|---|
| TESTED APPLICATIONS: | IF, IHC, WB |
| APPLICATIONS: | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200 |
| PREDICTED MOLECULAR WEIGHT: | 210 kDa |
| SPECIFICITY: | This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429. |
| IMMUNOGEN: | ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | Store antibody at -20˚C for up to one year. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, BHLHE39, Abelson murine leukemia viral oncogene homolog 1 |
|---|---|
| ACCESSION NO.: | NP_005148.2 / NP_001129472.1 |
| PROTEIN GI NO.: | 62362414 / 209862772 |
| OFFICIAL SYMBOL: | ABL1 ABL2 |
| GENE ID: | 25 / 27 |
Background
| BACKGROUND: | Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. |
|---|---|
| REFERENCES: | 1) Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259. |
品牌介绍
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