Prosci/ABIN3 Antibody/5303/0.1 mg
商品编号：
5303
品牌：
prosci-inc
市场价：
¥6500.00
美元价：
3900.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human, Mouse |
|---|---|
| TESTED APPLICATIONS: | ELISA, IHC-P, WB |
| APPLICATIONS: | ABIN3 antibody can be used for detection of ABIN3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| POSITIVE CONTROL: | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
| IMMUNOGEN: | ABIN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3. The immunogen is located within the last 50 amino acids of ABIN3. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | ABIN3 Antibody is affinity chromatography purified via peptide column. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | ABIN3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | ABIN3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | ABIN3 Antibody: LIND, ABIN-3, ABIN3, LIND, TNFAIP3-interacting protein 3, A20-binding inhibitor of NF-kappa-B activation 3 |
|---|---|
| ACCESSION NO.: | NP_079149 |
| PROTEIN GI NO.: | 192807305 |
| OFFICIAL SYMBOL: | TNIP3 |
| GENE ID: | 79931 |
Background
| BACKGROUND: | ABIN3 Antibody: The nuclear factor NF-κB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-κB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-κB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-κB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-κB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-κB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist. |
|---|---|
| REFERENCES: | 1) Verstrepen L, Carpentier I, Verhelst K, et al. Abins: A20 binding inhibitors of NFkappaB and apoptosis signaling. Biochem. Pharmacol.2009; 78:105-14. | 2) Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNFα/NFkappaB signal transduction pathway. Nat. Cell Biol.2004; 6:97-105. | 3) Wullaert A, Verstrepen L, Van Huffel S, et al. LIND/Abin-3 is a novel lipopolysaccharide-inducible inhibitor of NFkappaB activation. J. Biol. Chem.2007; 282:81-90. | 4) Weaver BK, Bohn E, Judd BA, et al. Abin-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol. Cell. Biol.2007; 27:4603-16. |
品牌介绍
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