Prosci/ABIN3 Antibody/5303/0.02 mg
商品编号：
5303
品牌：
prosci-inc
市场价：
¥1580.00
美元价：
948.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human,Mouse |
|---|---|
| TESTEDAPPLICATIONS: | ELISA,IHC-P,WB |
| APPLICATIONS: | ABIN3antibodycanbeusedfordetectionofABIN3byWesternblotat1μg/mL.Antibodycanalsobeusedforimmunohistochemistrystartingat5μg/mL. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1306-HumanSpleenTissueLysate |
| IMMUNOGEN: | ABIN3antibodywasraisedagainsta17aminoacidsyntheticpeptidenearthecarboxyterminusofhumanABIN3. Theimmunogenislocatedwithinthelast50aminoacidsofABIN3. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | ABIN3Antibodyisaffinitychromatographypurifiedviapeptidecolumn. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | ABIN3AntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | ABIN3antibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | ABIN3Antibody:LIND,ABIN-3,ABIN3,LIND,TNFAIP3-interactingprotein3,A20-bindinginhibitorofNF-kappa-Bactivation3 |
|---|---|
| ACCESSIONNO.: | NP_079149 |
| PROTEINGINO.: | 192807305 |
| OFFICIALSYMBOL: | TNIP3 |
| GENEID: | 79931 |
Background
| BACKGROUND: | ABIN3Antibody:ThenuclearfactorNF-κBplayskeyrolesindevelopmentandimmunity.ABIN3(A20-bindinginhibitorofNF-κBactivation3),alsoknownasTNFAIP3-interactingprotein3(TNIP3),isanovelnegativefeedbackregulatorofLPS-inducedNF-κBactivation.ABIN3isa39kDaproteinthatnegativelyregulatesNF-κBactivationinresponsetoTNFandLPS.ABIN3ishighlyexpressedinbrain,thymus,lymphnode,lungandfetalliver,withlowexpressioninkidney,bonemarrow.ThroughitsinteractionwithA20,ABIN3interfereswithTRAF2-mediatedtransactivationsignalsandNF-κBinhibitionismediatedbytheABIN-homologydomain2.ABIN3hasbeenfoundtobeinducedbyListeriainfectionandcanbeslightlydownregulatedbydexamethasone.EnhancedexpressionofABIN3inmonocytesisassociatedwithsepsis.Thus,ABIN3isanIL-10-inducedgeneproductcapableofattenuatingNF-κBinhumanmacrophagesyetisinoperativeinmiceandrepresentsabasisforspecies-specificdifferencesinIL-10actions.AtleastfourisoformsofABIN3areknowntoexist. |
|---|---|
| REFERENCES: | 1)VerstrepenL,CarpentierI,VerhelstK,etal.Abins:A20bindinginhibitorsofNFkappaBandapoptosissignaling.Biochem.Pharmacol.2009;78:105-14. | 2)BouwmeesterT,BauchA,RuffnerH,etal.AphysicalandfunctionalmapofthehumanTNFα/NFkappaBsignaltransductionpathway.Nat.CellBiol.2004;6:97-105. | 3)WullaertA,VerstrepenL,VanHuffelS,etal.LIND/Abin-3isanovellipopolysaccharide-inducIBLeinhibitorofNFkappaBactivation.J.Biol.Chem.2007;282:81-90. | 4)WeaverBK,BohnE,JuddBA,etal.Abin-3:amolecularbasisforspeciesdivergenceininterleukin-10-inducedanti-inflammatoryactions.Mol.Cell.Biol.2007;27:4603-16. |
品牌介绍
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