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Prosci/APRIL H98 multimeric Recombinant Protein/90-272/10 ug
Prosci/APRIL H98 multimeric Recombinant Protein/90-272/10 ug
商品编号：
90-272
品牌：
prosci-inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human, Mouse |
|---|---|
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | The extracellular domain of human APRIL (aa 98-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a DDDDK-tag. |
| FUSION TAG: | DDDDK Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Stimulates B cell proliferation. |
Properties
| PURITY: | >95% (SDS-PAGE) |
|---|---|
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Contains PBS + 0.5% Trehalose. |
| CONCENTRATION: | 0.1mg/ml after reconstitution. |
| STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at -20˚C. |
Additional Info
| ALTERNATE NAMES: | ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand: |
|---|---|
| ACCESSION NO.: | O75888 |
| PROTEIN GI NO.: | 4507599 |
Background
| APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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