Prosci/ANG-2 Recombinant Protein/40-540/0.02 mg
商品编号：
40-540
品牌：
prosci-inc
市场价：
¥4500.00
美元价：
2700.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | CHOcells |
| SEQUENCE: | DAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADFHHHHHH |
| TESTEDAPPLICATIONS: | |
| BIOLOGICALACTIVITY: | BiologicalactivitywasdeterminedbyitsABIlitytostimulatetubulogenesisinHUVECcellsusingaconcentrationof0.2μg/mL.Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
Properties
| PURITY: | Greaterthan95%bySDS-PAGEgelandHPLCanalyses. |
|---|---|
| PHYSICALSTATE: | Lyophilized |
| STORAGECONDITIONS: | ThelyophilizedANG-2recombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedANG-2isstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingYeastANG-2recombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
AdditionalInfo
| ALTERNATENAMES: | ANG2,AGPT2,Angiopoietin-2,ANG-2 |
|---|---|
| ACCESSIONNO.: | NP_001112359.1 |
| PROTEINGINO.: | 169646749 |
Background
| ANG-2bindstotheendothelialcellspecificreceptorTie2,but,incontrasttoANG-1doesnotinducetyrosinephosphorylation.Consequently,ANG-2modulatesANG-1activationofTie2and,dependingonthephysiologicalandbiochemicalenvironment,canacteitherasanagoNISTorantagonistofTie2inducedangiogenesis.ThesignalinginteractionsofANG-1,ANG-2andTie2,alongwithlesscharacterizedANG-3andANG-4,arerequiredforembryonicandadultangiogenesis.Physiologically,ANG-1andANG-2areassociatedwithsprouting,tubeformation,andstructuralintegrityofnewlyformedbloodvessels.MaturehumanANG-2isasecretedproteincontaining480aminoacidresidues.ANG-2iscomposedofanalphahelixrich"coiledcoil”N-terminaldomainandfibrinogenlikeC-terminaldomain.ANG-2existspredominantlyintheformofadisulfide-linkeddimer.RecombinanthumanANG-2isaC-terminalhistidinetaggedglycoproteinwhichmigrateswithanapparentmolecularmassof60.0-70.0kDabySDS-PAGEunderreducingconditions.SequencinganalysisshowsanN-terminalsequencestartingwithresidue68(D)oftheANG-2precursorprotein. |
品牌介绍
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