Prosci/ANG-1 Recombinant Protein/40-229/0.005 mg
商品编号：
40-229
品牌：
prosci-inc
市场价：
¥3100.00
美元价：
1860.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HeLacells |
| TESTEDAPPLICATIONS: | |
| BIOLOGICALACTIVITY: | Biologicalactivitywasdeterminedbythedose-dependentstimulationoftheproliferationofhumanumbilicalveinendothelialcells(HUVEC). |
Properties
| PURITY: | Greaterthan95%bySDS-PAGEgelandHPLCanalyses. Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
|---|---|
| PHYSICALSTATE: | Lyophilized |
| STORAGECONDITIONS: | ThelyophilizedANG-1recombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedANG-1isstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingANG-1recombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
AdditionalInfo
| ALTERNATENAMES: | AGP1,AGPT,ANG1,KIAA0003,Angiopoietin-1,ANG-1 |
|---|---|
| ACCESSIONNO.: | NP_001137.2 |
| PROTEINGINO.: | 20532340 |
Background
| Angiopoietin-1(Ang-1)isasecretedligandforTie-2,atyrosine-kinasereceptorexpressedprimarilyonvascularendothelialcellsandearlyhematopoieticcells.Ang-1/Tie-2signalingpromotesangiogenesisduringthedevelopment,remodeling,andrepairofthevascularsystem.TransgenicmicelackingexpressionofeitherAng-1orTie-2failtodevelopafullyfunctionalcardiovascularsystemanddiebeforebirth.Postnatally,theangiogenicactivityofAng-1/Tie-2isrequiredduringnormaltissuerepairandremodelingofthefemaleendometriuminthemenstrualcycle.Ang-1/Tie-2signalingappearstoberegulatedbyAngiopoietin-2(Ang-2),anaturalantagoNISTforTie-2thatexertsitseffectsthroughaninternalautocrineloopmechanism.Inadditiontosuppressingendothelialcellactivationbyinhibitingtheexpressionofadhesionandinflammatorymolecules,Ang-1enhancesendothelialcellsurvivalandcapillarymorphogenesis,andlessenscapillarypermeABIlity.Assuch,Ang-1hasapotentialtobecomeaneffectivetherapeuticagentfortreatingvariousendotheliumdisorders,includingseveralseverehumanpulmonarydiseases.Theefficacyofcell-basedAng-1genetherapyforacutelunginjury(ALI)hasrecentlybeenstudiedinaratmodelofALI(1).TheresultsofthisstudyshowthatsuchtherapycanmarkedlyimprovelungconditionandsuggestthatAng-1therapymayrepresentapotentialnewstrategyforthetreatmentand/orpreventionofacuterespiratorydistressinjury(ARDI),asignificantcauseofmorbidityandmortalityincriticallyillpatients.RecombinanthumanANG-1,derivedfromHeLacells,isaC-terminalhistidinetaggedglycoproteinwhichmigrateswithanapparentmolecularmassof60.0-70.0kDabySDS-PAGEunderreducingconditions.SequencinganalysisshowsN-terminalsequencesstartingwithSer-20andwithAsp-70ofthe498aminoacidprecursorprotein. |
品牌介绍
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