Prosci/ABCB1 Antibody/48-673/0.05 mg
商品编号：
48-673
品牌：
prosci-inc
市场价：
¥9000.00
美元价：
5400.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Dog, Human, Monkey, Mouse, Rat |
|---|---|
| TESTED APPLICATIONS: | ELISA, IHC, WB |
| APPLICATIONS: | ABCB1 antibody can be used in Western Blot, and immunohistochemistry starting at 2.5 μg/mL. |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| IMMUNOGEN: | ABCB1 antibody was raised against amino acids 262 - 277 of ABCB1 (Human). |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | Immunoaffinity Chromatography |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
| STORAGE CONDITIONS: | Antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, Doxorubicin resistance, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1 |
|---|---|
| ACCESSION NO.: | P08183 |
| PROTEIN GI NO.: | 238054374 |
| OFFICIAL SYMBOL: | ABCB1 |
| GENE ID: | 5243 |
Background
| BACKGROUND: | ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier. |
|---|
品牌介绍
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