Prosci/ABCA7抗体/6889/0.1mg
商品编号：
6889
品牌：
prosci-inc
市场价：
¥6500.00
美元价：
3900.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| APPLICATIONS: | ABCA7antibodycanbeusedfordetectionofABCA7byWesternblotat1-2μg/mL.Antibodycanalsobeusedforimmunocytochemistrystartingat5μg/mLandimmunohistochemistrystartingat5μg/mL.Forimmunofluorescencestartat5μg/mL. |
|---|---|
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1210-HEK293CellLysate |
| 2)Cat.No.10-901-HumanSpleenTissueSlide | |
| 3)Cat.No.17-010-HEK293CellSlide | |
| PREDICTEDMOLECULARWEIGHT: | Predicted:236kDa Observed:240kDa |
| SPECIFICITY: | ABCA7antibodyispredictedtonotcross-reactwithotherABC1subfamilyproteins. |
| IMMUNOGEN: | ABCA7antibodywasraisedagainstan18aminoacidsyntheticpeptideneartheaminoterminusofhumanABCA7. Theimmunogenislocatedwithinaminoacids130-180ofABCA7. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | ABCA7Antibodyisaffinitychromatographypurifiedviapeptidecolumn. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | ABCA7AntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | ABCA7antibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | ABCA7Antibody:ABCX,ABCA-SSN,ATP-bindingcassettesub-familyAmember7 |
|---|---|
| ACCESSIONNO.: | NP_061985 |
| PROTEINGINO.: | 150417984 |
| OFFICIALSYMBOL: | ABCA7 |
| GENEID: | 10347 |
Background
| BACKGROUND: | ABCA7Antibody:ATP-bindingcassette(ABC)transportersareanevolutionarilyconservedfamilythatuseATPhydrolysistocatalyzethetransportofvariousmoleculesacrosscellmembranes.Theyaredividedintosevendistinctsubfamilies(ABC1,MDR/TAP,MRP,ALD,OABP,GCN20,White).ABCA7,amemberoftheABC1subfamily,isafull-sizeABCtransporterconsistingoftwosetsofthemultiplemembrane-spanningdomainsplustheWalkermotifsfortheATPinteraction.ABCA7showsthehighesthomologytoABCA1,anessentialmoleculeforcholesterolhomeostasis.ThehighexpressionlevelsofABCA7inperipheralleukocytes,thymus,spleenandbonemarrowsuggestsaroleintheimmunesystemlipidhomeostasis. |
|---|---|
| REFERENCES: | 1)KaminskiWE,OrsóE,DiederichW,etal.Identificationofanovelhumansterol-sensitiveATP-bindingcassettetransporter(ABCA7).Biochem.Biophys.Res.Commun.2000;273:532-8. | 2)Abe-DohmaeS,UedaK,andYokoyamaS.ABCA7,amoleculewithunknownfunction.FEBSLett.2006;580:1178-82 | 3)IkedaY,Abe-DohmaeS,MunehiraY,etal.2003.Post-transcriptionalregulationofhumanABCA7anditsfunctionfortheapoA-I-dependentlipidrelease.Biochem.Biophys.Res.Commun.311:313-8. | 4)IwamotoN,Abe-DohmaeS,SatoR,etal.ABCA7expressionisregulatedbycellularcholesterolthroughtheSREBP2pathwayandassociatedwithphagocytosis.J.LipidRes.2006;47:1915-27. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
联络我们
