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当前位置: 首页 > 产品中心 > Recombinant_antibodies > Prosci/ABAT抗体/26-612/50微克
商品详细Prosci/ABAT抗体/26-612/50微克
Prosci/ABAT抗体/26-612/50微克
Prosci/ABAT抗体/26-612/50微克
商品编号: 26-612
品牌: prosci-inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
公司:
产品分类: 重组抗体
公司分类: Recombinant_antibodies
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Specifications

SPECIES REACTIVITY:Mouse, Rat
TESTED APPLICATIONS:WB
APPLICATIONS:ABAT antibody can be used for detection of ABAT by ELISA at 1:12500. ABAT antibody can be used for detection of ABAT by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1309 - Human Placenta Lysate
PREDICTED MOLECULAR WEIGHT:55 kDa
IMMUNOGEN:Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ABAT.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Antibody is purified by peptide affinity chromatography method.
PHYSICAL STATE:Lyophilized
BUFFER:Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:For short periods of storage (days) store at 4˚C. For longer periods of storage, store ABAT antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ABAT, GABA-AT, GABAT, NPD009
ACCESSION NO.:NP_065737
PROTEIN GI NO.:38679946
OFFICIAL SYMBOL:ABAT
GENE ID:18

Background

BACKGROUND:4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
REFERENCES: 1) Inada, T., (2008) Pharmacogenet. Genomics 18 (4), 317-323.
品牌介绍
 ProSci我们是抗体开发公司中的领导者。我们的研究抗体,定制抗体开发服务和领先的研究计划可帮助科学家,实验室技术人员,研究人员和其他技术人员降低研究成本,灵活而广泛的抗体服务,在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。