Prosci/ABAT抗体/26-612/50微克
商品编号:
26-612
品牌:
prosci-inc
市场价:
¥6500.00
美元价:
3900.00
产品分类:
重组抗体
公司分类:
Recombinant_antibodies
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Specifications
SPECIES REACTIVITY: | Mouse, Rat |
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TESTED APPLICATIONS: | WB |
APPLICATIONS: | ABAT antibody can be used for detection of ABAT by ELISA at 1:12500. ABAT antibody can be used for detection of ABAT by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. |
USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
POSITIVE CONTROL: | 1) Cat. No. 1309 - Human Placenta Lysate |
PREDICTED MOLECULAR WEIGHT: | 55 kDa |
IMMUNOGEN: | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ABAT. |
HOST SPECIES: | Rabbit |
Properties
PURIFICATION: | Antibody is purified by peptide affinity chromatography method. |
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PHYSICAL STATE: | Lyophilized |
BUFFER: | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
CONCENTRATION: | 1 mg/ml |
STORAGE CONDITIONS: | For short periods of storage (days) store at 4˚C. For longer periods of storage, store ABAT antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
CLONALITY: | Polyclonal |
CONJUGATE: | Unconjugated |
Additional Info
ALTERNATE NAMES: | ABAT, GABA-AT, GABAT, NPD009 |
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ACCESSION NO.: | NP_065737 |
PROTEIN GI NO.: | 38679946 |
OFFICIAL SYMBOL: | ABAT |
GENE ID: | 18 |
Background
BACKGROUND: | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
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REFERENCES: | 1) Inada, T., (2008) Pharmacogenet. Genomics 18 (4), 317-323. |
品牌介绍
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