Prosci/AATF Antibody/3039/0.02 mg
商品编号：
3039
品牌：
prosci-inc
市场价：
¥1580.00
美元价：
948.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human,Mouse |
|---|---|
| TESTEDAPPLICATIONS: | ELISA,IF,IHC-P,WB |
| APPLICATIONS: | AATFantibodycanbeusedforthedetectionofAATFbyWesternblotat0.5-2μg/mL.Antibodycanalsobeusedforimmunohistochemistrystartingat10μg/mL.Forimmunofluorescencestartat20μg/mL. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1308-HumanSmallIntestineTissueLysate |
| 2)Cat.No.11-801-HumanSmallIntestineTissueSlide | |
| IMMUNOGEN: | AATFantibodywasraisedagainsta12aminoacidsyntheticpeptidefromnearthecarboxyterminusofhumanAATF. Theimmunogenislocatedwithinthelast50aminoacidsofAATF. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | AATFAntibodyisimmunoaffinitypurifiedIgG. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | AATFAntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | AATFantibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | AATFAntibody:DED,BFR2,CHE1,CHE-1,DED,HSPC277,ProteinAATF,Apoptosis-antagonizingtranscriptionfactor |
|---|---|
| ACCESSIONNO.: | NP_036270 |
| PROTEINGINO.: | 7657013 |
| OFFICIALSYMBOL: | AATF |
| GENEID: | 26574 |
Background
| BACKGROUND: | AATFAntibody:AATF(apoptosisantagonizingtranscriptionfactor)wasinitiallydiscoveredasaninteractionpartnerofZIPkinase(ZIPK),amemberofdeath-associatedprotein(DAP)kinasefamilyofpro-apoptoticserine/threoninekinases.AATFisaphosphoproteincontaininganacidicregionandaputativeleucinezipperdomainandnuclearlocalizationsignal,featureswhicharetypicaloftranscriptionfactors.AATFinhibitstheZIPK-mediatedpro-apoptoticpathwayandmayactivateotheranti-apoptoticpathways.Recently,ithasalsobeenshowntoprotectneuralcellsagainstoxidativedamageinducedbyamyloidb-peptideandtoinhibitaberrantproductionofthebeta-peptidebyinteractingwithPar-4(prostateapoptosisresponse-4),anotherpro-apoptoticleucinezipperproteinthatisassociatedwithneuronaldegenerationinAlzheimer"sdisease(AD),suggestingthatAATFmayhavepotentialtherapeuticapplicationsinbothfamilialandsporADIcformsofAD. |
|---|---|
| REFERENCES: | 1)AATFantibodycanbestoredat4˚C,stableforoneyear.PageG,LodigeI,KogelDetal.AATF,anoveltranscriptionfactorthatinteractswithDlk/ZIPkinaseandinterfereswithapoptosis.FEBSLett.1999;462:187-191. | 2)KawaiT,MatsumotoM,TakedaK,etal.ZIPkinase,anovelserine/threoninekinasewhichmediatesapoptosis.Mol.CellBiol.1998;18:1642-51. | 3)LindforsK,HalttunenT,HuotariP,etal.Identificationofnoveltranscriptionfactor-likegenefromhumanintestinalcells.Biochem.Biophys.Res.Commun.2000;276:660-6. | 4)XieJandGuoQ.AATFprotectsneuralcellsagainstoxidativedamageinducedbyamyloidb-peptide.Neurobiol.ofDis.2004;16:150-7. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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