Prosci/ALK 1重组蛋白/96-022/0.1mg
商品编号：
96-022
品牌：
prosci-inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Asp 22 - Gln 118 |
| FUSION TAG: | His Tag |
| TESTED APPLICATIONS: | WB |
| APPLICATIONS: | This recombinant protein can be used for WB. For research use only. |
Properties
| PURITY: | >97% as determined by SDS-PAGE. |
|---|---|
| PREDICTED MOLECULAR WEIGHT: | 12.3 kDa |
| PHYSICAL STATE: | Lyopholized |
| BUFFER: | PBS, pH7.4 |
| STORAGE CONDITIONS: | Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles. |
Additional Info
| ALTERNATE NAMES: | ACVRL1, ACVRLK1, ALK-1, HHT, HHT2, ORW2, SKR3, TSR-I |
|---|---|
| ACCESSION NO.: | NP_000011.2 |
Background
| Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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