Prosci/激活素A重组蛋白/96-912/100微克
商品编号：
96-912
品牌：
prosci-inc
市场价：
¥10500.00
美元价：
6300.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Ser21-Ser426 |
| FUSIONTAG: | HisTag |
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedHumanActivinA,HisTagat10ug/mL(100uL/well)canbindHumanACVR2A,FcTagwithalinearrangeof0.625-20ug/mL(QCtested). |
Properties
| PURITY: | >90%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 13kDa(mature)&32kDa(pro) |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | PBS,pH7.4 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | ActivinA,INHBA |
|---|---|
| ACCESSIONNO.: | AAH07858.1 |
Background
| Activinandinhibinaretwocloselyrelatedproteincomplexesthathavealmostdirectlyoppositebiologicaleffects.ActivinenhancesFSHbiosynthesisandsecretion,andparticipatesintheregulationofthemenstrualcycle.Manyotherfunctionshavebeenfoundtobeexertedbyactivin,includingrolesincellproliferation,differentiation,apoptosis,metabolism,homeostasis,immuneresponse,woundrepair,andendocrinefunction.ConverselyinhibindownregulatesFSHsynthesisandinhibitsFSHsecretion.Activinsarenonglycosylatedhomodimersorheterodimersofvariousbetasubunits(betaA,betaB,betaC,andbetaEinmammals),whileInhibinsareheterodimersofauniquealphasubunitandoneofthebetasubunits.ActivinAisawidelyexpressedhomodimeroftwobetaAchains.ThebetaAsubunitcanalsoheterodimerizewithabetaBorbetaCsubunittoformActivinABandActivinAC,respectively.The14kDamaturehumanbetaAchainshares100%aminoacidsequenceidentitywithbovine,feline,mouse,porcine,andratbetaA.Activinisproducedinthegonads,pituitarygland,placenta,andotherorgans.ThebioactivityofActivinAisregulatedbyavarietyofmechanisms.Intheovarianfollicle,activinincreasesFSHbindingandFSH-inducedaromatization;Activinisstronglyexpressedinwoundedskin,andoverexpressionofactivininepidermisoftransgenicmiceimproveswoundhealingandenhancesscarformation;Activinalsoregulatesthemorphogenesisofbranchingorganssuchastheprostate,lung,andespeciallykidney.ActivinAincreasedtheexpressionleveloftype-IcollagensuggestingthatactivinAactsasapotentactivatoroffibroblasts;Lackofactivinduringdevelopmentresultsinneuraldevelopmentaldefects. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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