Prosci/4-1BB重组蛋白/96-790/100μg
商品编号：
96-790
品牌：
prosci-inc
市场价：
¥9500.00
美元价：
5700.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES: | Cynomolgus,Rhesusmacaque |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Leu24-Gln186 |
| FUSIONTAG: | HisTag |
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedCynomolgus/Rhesusmacaque4-1BB,HisTagat1ug/mL(100uL/well)canbindHuman4‑1BBLigand,FcTagwithalinearrangeof0.05-0.5ng/mL(QCtested). |
Properties
| PURITY: | >92%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 19.2kDa |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | PBS,pH7.4 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | 4-1BB |
|---|---|
| ACCESSIONNO.: | XP_005544945.1 |
Background
| 4-1BBisalsoknownasCD137,tumornecrosisfactorreceptorsuperfamilymember9(TNFRSF9),inducedbylymphocyteactivation(ILA),isaco-stimulatorymoleculeofthetumornecrosisfactor(TNF)receptorsuperfamily.CD137canbeexpressedbyactivatedTcells,buttoalargerextentonCD8thanonCD4Tcells.Inaddition,CD137expressionisfoundondendriticcells,folliculardendriticcells,naturalkillercells,granulocytesandcellsofbloodvesselwallsatsitesofinflammation.ThebestcharacterizedactivityofCD137isitscostimulatoryactivityforactivatedTcells.CrosslinkingofCD137enhancesTcellproliferation,IL-2secretionsurvivalandcytolyticactivity.Further,itcanenhanceimmuneactivitytoeliminatetumorsinmice.CD137canenhanceactivation-inducedTcellapoptosiswhentriggeredbyengagementoftheTCR/CD3complex.Inaddition,4-1BB/4-1BBLco-stimulatorypathwayhasbeenshowntoaugmentsecondaryCTLresponsestoseveralviruses,andmeanwhileaugmentanti-tumorimmunity.4-1BBthusisapromisingcandidateforimmunotherapyofhumancancer.CD137hasbeenshowntointeractwithTRAF2. |
品牌介绍
ProSci我们是抗体开发公司中的领导者。我们的研究抗体，定制抗体开发服务和领先的研究计划可帮助科学家，实验室技术人员，研究人员和其他技术人员降低研究成本，灵活而广泛的抗体服务，在线支持以及丰富的抗体使用第一手知识因为它们与特定的免疫化学应用有关。
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