Prosci/A-RAF抗体/63-215/400微升
商品编号：
63-215
品牌：
prosci-inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIES REACTIVITY: | Human |
|---|---|
| TESTED APPLICATIONS: | IHC-P, WB |
| APPLICATIONS: | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| PREDICTED MOLECULAR WEIGHT: | 68 kDa |
| IMMUNOGEN: | This A-RAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the Central region of human A-RAF. |
| HOST SPECIES: | Rabbit |
Properties
| PURIFICATION: | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | 2 mg/ml |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | Serine/threonine-protein kinase A-Raf, Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Proto-oncogene Pks, ARAF, ARAF1, PKS, PKS2 |
|---|---|
| ACCESSION NO.: | P10398 |
| PROTEIN GI NO.: | 1730068 |
| OFFICIAL SYMBOL: | ARAF |
| GENE ID: | 369 |
Background
| BACKGROUND: | Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway. |
|---|---|
| REFERENCES: | 1) Wu, X., et al., J. Biol. Chem. 271(6):3265-3271 (1996). | 2) Lee, J.E., et al., Genomics 20(1):43-55 (1994). | 3) Popescu, N.C., et al., Oncogene 4(4):517-519 (1989). | 4) Beck, T.W., et al., Nucleic Acids Res. 15(2):595-609 (1987). |
品牌介绍
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