Prosci/27Kip1 Antibody/62-207/400 ul
商品编号：
62-207
品牌：
prosci-inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predictedspeciesreactivitybasedonimmunogensequence:Hamster |
| TESTEDAPPLICATIONS: | IF,WB |
| APPLICATIONS: | ForWBstartingdilutionis:1:1000 ForIFstartingdilutionis:1:10~50 |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| PREDICTEDMOLECULARWEIGHT: | 22kDa |
| IMMUNOGEN: | This27Kip1antibodyisgeneratedfromrabbitsimmunizedwithaKLHconjugatedsyntheticpeptidebetween165-194aminoacidsfromtheC-terminalregionofhuman27Kip1. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | ThisantibodyispurifiedthroughaproteinAcolumn,followedbypeptideaffinitypurification. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | SuppliedinPBSwith0.09%(W/V)sodiumazide. |
| CONCENTRATION: | 0.42mg/ml |
| STORAGECONDITIONS: | Storeat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | RabbitIg |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | Cyclin-dependentkinaseinhibitor1B,Cyclin-dependentkinaseinhibitorp27,p27Kip1,CDKN1B,KIP1 |
|---|---|
| ACCESSIONNO.: | P46527 |
| OFFICIALSYMBOL: | CDKN1B |
| GENEID: | 1027 |
Background
| BACKGROUND: | p27Kip1isacyclin-dependentkinaseinhibitor,whichsharesalimitedsimilaritywithCDKinhibitorCDKN1A/p21.TheencodedproteinbindstoandpreventstheactivationofcyclinE-CDK2orcyclinD-CDK4complexes,andthuscontrolsthecellcycleprogressionatG1.Thedegradationofthisprotein,whichistriggeredbyitsCDKdependentphosphorylationandsubsequentubiquitinationbySCFcomplexes,isrequiredforthecellulartransitionfromquiescencetotheproliferativestate. |
|---|---|
| REFERENCES: | 1)Kawamata,N.,etal.,Eur.J.Haematol.74(5):424-429(2005). | 2)Andreu,E.J.,etal.,CancerRes.65(8):3264-3272(2005). | 3)Wingate,H.,etal.,J.Biol.Chem.280(15):15148-15157(2005). | 4)Wang,C.,etal.,J.Biol.Chem.280(13):12339-12343(2005). |
品牌介绍
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