Prosci/5脂氧合酶（磷酸化Ser523）抗体/50-244/0.1 mL
商品编号：
50-244
品牌：
prosci-inc
市场价：
¥9000.00
美元价：
5400.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human,Rat |
|---|---|
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | TheantibodyhasbeendirectlytestedforreactivityinWesternblotswithratandhumantissue.Itisanticipatedthattheantibodywillreactwithnonhumanprimatesbasedonthefactthatthesespecieshave100%homologywiththeaminoacidsequenceusedasantigen. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| PREDICTEDMOLECULARWEIGHT: | 80 |
| IMMUNOGEN: | Phosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser523ofhuman5-lipoxygenase(5-LO). |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | AffinityPurified |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | 100uLin10mMHEPES(pH7.5),150mMNaCl,100ugpermLBSAand50%glycerol. |
| STORAGECONDITIONS: | 5Lipoxygenaseantibodycanbestoredat-20˚Candisstableat-20˚Cforatleast1year. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | 5-LO,5LPG,LOG5,5-LOX, |
|---|---|
| ACCESSIONNO.: | P09917 |
| PROTEINGINO.: | 126407 |
| OFFICIALSYMBOL: | ALOX5 |
| GENEID: | 240 |
Background
| BACKGROUND: | Theenzyme5-lipoxygenase(5-LO)playsakeyroleinregulatingtheproductionofleukotrienes(LTs)(Funk,2001).OverproductionofLTscontributestoseveraldiseases,mostnotablychronicinflammatorydiseases,includingasthma(Drazenetal.,1994),fibrosis(Wilbornetal.,1996)andatherosclerosis(Dwyeretal.,2004).Recentworkhasdemonstratedthattheactivityof5-LOisregulatedbyPKAphosphorylationofserine-523in5-LO(Luoetal.,2004).Undernormalconditions,thisphosphorylationmaybeimportantinlimitinginflammation.AbnormalsignalingthroughcAMPandPKA,then,couldcontributetoavarietyofdiseases,includingthosecharacterizedbychronicinflammation.Thephospho-specificantibodytoSer523on5-LOisthuslikelytoprovideavaluabletoolforstudiesoftheroleof5-LOregulationindiseasessuchasasthma,fibrosisandatherosclerosis. |
|---|---|
| REFERENCES: | 1)DrazenJM,LillyCM,SperlingR,RubinP,IsraelE(1994)Roleofcysteinylleukotrienesinspontaneousasthmaticresponses.Adv.ProstaglandinThromboxaneLeukotRes22:251-262. | 2)DwyerJH,AllayeeH,DwyerKM,FanJ,WuH,MarR,LusisAJ,MehrABIanM(2004)Arachidonate5-lipoxygenasepromotergenotype,dietaryarachidonicacid,andatherosclerosis.NewEnglandJMed350:29-37. | 3)Funk,CD(2001)Prostaglandinsandleukotrienes:advancesineicosanoidBIOLOGy.Science294:1871-1875. |
品牌介绍
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