Prosci/4E-BP1抗体/3513/0.02 mg
商品编号：
3513
品牌：
prosci-inc
市场价：
¥1580.00
美元价：
948.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Specifications
| SPECIESREACTIVITY: | Human,Mouse |
|---|---|
| HOMOLOGY: | Predictedspeciesreactivitybasedonimmunogensequence:Rat:(100%),Bovine:(92%) |
| TESTEDAPPLICATIONS: | ELISA,ICC,IF,WB |
| APPLICATIONS: | 4E-BP1antibodycanbeusedforthedetectionof4E-BP1byWesternblotat2.5-10μg/mL.Antibodycanalsobeusedforimmunocytochemistrystartingat2μg/mL.Forimmunofluorescencestartat20μg/mL. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1212-3T3CellLysate |
| 2)Cat.No.17-201-3T3/BALBCellSlide | |
| IMMUNOGEN: | 4E-BP1antibodywasraisedagainsta14aminoacidsyntheticpeptidefromnearthecarboxyterminusofhuman4E-BP1. Theimmunogenislocatedwithinthelast50aminoacidsof4E-BP1. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | 4E-BP1Antibodyisaffinitychromatographypurifiedviapeptidecolumn. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | 4E-BP1AntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | 4E-BP1antibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | 4E-BP1Antibody:BP-1,4EBP1,4E-BP1,PHAS-I,Eukaryotictranslationinitiationfactor4E-bindingprotein1,Phosphorylatedheat-andacid-stableproteinregulatedbyinsulin1 |
|---|---|
| ACCESSIONNO.: | NP_004086 |
| PROTEINGINO.: | 4758258 |
| OFFICIALSYMBOL: | EIF4EBP1 |
| GENEID: | 1978 |
Background
| BACKGROUND: | 4E-BP1Antibody:ThetranslationofmRNAineukaryoticcellsisregulatedbythepresenceofaminoacidsthroughmultiplemechanisms.Onesuchmechanisminvolvestheevolutionarilyconservedserine/threoninekinaseTOR(Targetofrapamycin,alsoknownasmTOR),whichregulatescellgrowthandcellcyclethroughitsABIlitytointegratesignalsfromnutrientlevelsandgrowthfactors.OnedownstreamtargetofTORistheeukaryoticinitiationfactor4Ebindingprotein1(4E-BP1)whosephosphorylationpreventsitsassociationwitheIF4E,preferentiallystimulatingtranslationofmRNAscontaininglong,highlystructured5"-UTRs.RapamycininhibitsTORresultinginreducedcellgrowthandreducedratesofcellcycleandcellproliferationl,atleastinpartbyinhibitingtheactivityofTORtowards4E-BP1. |
|---|---|
| REFERENCES: | 1)ShahOJ,AnthonyJC,KimballSR,etal.4E-BP1andS6K1:translationalintegrationsitesfornutritionalandhormonalinformationinmuscle.Am.J.Physiol.Endocrinol.Metab.2000;279:E715-29. | 2)ShamjiAF,NgheimP,andSchreiberSL.Integrationofgrowthfactorandnutrientsignaling:implicationsforcancerBIOLOGy.Mol.Cell2003;12:271-80. |
品牌介绍
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